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G Protein-Coupled Receptor Kinases de Vsevolod V. Gurevich

G Protein-Coupled Receptor Kinases: Methods in Pharmacology and Toxicology

Editat de Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer
en Limba Engleză Hardback – 21 iul 2016
This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. 
Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.
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Specificații

ISBN-13: 9781493937967
ISBN-10: 1493937960
Pagini: 408
Ilustrații: XI, 329 p. 36 illus., 33 illus. in color.
Dimensiuni: 178 x 254 x 21 mm
Greutate: 0.81 kg
Ediția:1st ed. 2016
Editura: Springer
Colecția Humana
Seria Methods in Pharmacology and Toxicology

Locul publicării:New York, NY, United States

Cuprins

G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery.- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7.- Visual G Protein-Coupled Receptor Kinases.- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily.- “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs.- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications.- Differential Regulation of IGF-1 and Insulin Signaling by GRKs.- Differential Control of Potassium Channel Activity by GRK2.- Critical Role of GRK2 in the Prevention of Chronic Pain.- Roles of GRK Dysfunction in Alzheimer’s Pathogenesis.- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases.- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation.- GRK Roles in C. elegans.- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.

Textul de pe ultima copertă

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. 
Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Caracteristici

Features detailed examinations of known GRK-dependent mechanisms, both associated with GPCR functions and receptor-independent Covers a wide range of studies from invertebrates to humans Provides practical advice from the experts on how to continue research on GRKs Includes supplementary material: sn.pub/extras