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Delta Opioid Receptor Pharmacology and Therapeutic Applications de Emily M. Jutkiewicz

Delta Opioid Receptor Pharmacology and Therapeutic Applications: Handbook of Experimental Pharmacology, cartea 247

Editat de Emily M. Jutkiewicz
en Limba Engleză Hardback – 9 oct 2018
This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.
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Specificații

ISBN-13: 9783319951317
ISBN-10: 3319951319
Pagini: 340
Ilustrații: VIII, 348 p.
Dimensiuni: 155 x 235 mm
Greutate: 0.68 kg
Ediția:1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

Part 1. DOPR Ligands.- 1. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept.- 2. Multifunctional Opioid Ligands.- 3. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins.- Part 2. DOPR Signaling.- 4. Ligand-Directed Signaling at the Delta Opioid Receptor.- 5. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.- 6. Evidence and Function Relevance of Native DOR–MOR Heteromers.- Part 3. DOPR and Disease.- 8. The Delta Opioid Receptor in Pain Control.- 9. Delta Opioid Receptors and Modulation of Mood and Emotion.- 10. Delta Opioid Pharmacology in Relation to Alcohol Behaviors.- 11. Delta Opioid Receptors: Learning and Motivation.- 12. Delta Opioid Pharmacology in Parkinson’s Disease.- 13. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders.-14. Delta Opioid Receptors and Cardioprotection.- 15. The Roles of Opioid Receptors in Cutaneous Wound Healing. 

Caracteristici

Discusses emerging knowledge about the biological function of the delta opioid receptor Describes therapeutic potential of the delta opioid receptor system Describes unique trafficking and signaling properties of the delta opioid receptor