In this issue of Veterinary Clinics: Small Animal Practice, guest editor Dr. Christina V. Tran brings her considerable expertise to the topic of Diversity, Equity, and Inclusion in Veterinary Medicine, Part I. Top experts discuss the challenges and opportunities faced by the veterinary profession in meeting the needs of an increasingly diverse client base. A look back at the history of DEI efforts offers context for the ongoing need for systemic and organizational change. Articles also explore the connection between areas such as veterinary education, practice management, access to care, animal welfare, and leadership development in veterinary medicine through the lens of diversity, equity and inclusion.