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Impact of Survivin Acetylation on its Biological Function: BestMasters

Autor David Dannheisig
en Limba Engleză Paperback – 16 iun 2017
In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.
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Specificații

ISBN-13: 9783658186227
ISBN-10: 3658186224
Pagini: 104
Ilustrații: XXIII, 104 p. 41 illus., 10 illus. in color.
Dimensiuni: 148 x 210 mm
Greutate: 0.16 kg
Ediția:1st ed. 2017
Editura: Springer Fachmedien Wiesbaden
Colecția Springer Spektrum
Seria BestMasters

Locul publicării:Wiesbaden, Germany

Cuprins

Apoptosis – The Programmed Suicide.- Cancer – The Enemy Inside.- Nucleocytoplasmic Transport– Cellular Navigation.- Biological Function of Survivin.- Protein modification – Make-Up for Proteins.- Cell cycle – Virchow’s Heritage.

Notă biografică

David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.

Textul de pe ultima copertă

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. 

Contents
  • Apoptosis – The Programmed Suicide
  • Cancer – The Enemy Inside 
  • Nucleocytoplasmic Transport– Cellular Navigation
  • Biological Function of Survivin
  • Protein modification – Make-Up for Proteins
  • Cell cycle – Virchow’s Heritage
Target Groups
  • Lecturers, students and researchers in the biological-medical sector
  • Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies
The Author
David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.

Caracteristici

Study on the Biological Function of Survivin Includes supplementary material: sn.pub/extras