This issue of Veterinary Clinics: Small Animal Practice, guest edited by Drs. Karl Maritato and Matthew Barnhart, focuses on Minimally Invasive Fracture Repair. Articles in this issue include, but are not limited to: Biomechanics of Fracture Fixation;?Challenges in Minimally Invasive Fracture Repair;?Minimally Invasive Osteosynthesis Fracture Reduction Techniques;?Percutaneous Pinning for Fracture Repair;?Minimally Invasive Plate Osteosynthesis Techniques for the Humerus;?Minimally Invasive Plate Osteosynthesis Techniques for the Radius and Ulna;?Minimally Invasive Osteosynthesis (MIO) Techniques of the Femur;?Minimally Invasive Osteosynthesis Techniques for Articular Fractures;?Unique Differences of Minimally Invasive Fracture Repair in the Feline;?Perioperative Imaging in Minimally Invasive Osteosynthesis;?Interlocking Nails for Minimally Invasive Osteosynthesis;?Minimally Invasive Plate Osteosynthesis Techniques for Tibia and Fibula;?Minimally Invasive Plate Osteosynthesis Techniques for Meta-bones;?Minimally Invasive Osteosynthesis Techniques for Sacroiliac Luxation; and Minimally Invasive Plate Osteosynthesis Techniques for Arthrodesis.