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Neurobiology of TRP Channels: Frontiers in Neuroscience

Editat de Tamara Luti Rosenbaum Emir
en Limba Engleză Paperback – 18 dec 2020
During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli.




Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels.


Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.




Features:




• Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins.




• Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes.




• Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance.




• Features several full color illustrations to allow the reader better comprehension of TRP channels.




A volume in the Frontiers in Neuroscience series


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Specificații

ISBN-13: 9780367735807
ISBN-10: 0367735806
Pagini: 364
Dimensiuni: 178 x 254 mm
Greutate: 0.61 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Frontiers in Neuroscience


Public țintă

Academic and Professional Reference

Cuprins

TRP channels in Vision. Sensory Mechano Transduction and Thermotransduction in Worms. Osmomechanical-Sensitive TRP channels in Vertebrates. A critical Role for TRP channels in the Skin. Olfactory Transduction and its Coupling to TRP channels: Interactions with G proteins. The Neurobiology of Taste and TRP channels. The Molecular Basis of Thermosensation. TRP channels and Pain. The Role of TRP channels in the Gut. The Cardiovascular System and TRP channels. TRP channels in Renal Physiology. Fertility and TRP channels. TRP channels and the Endocrine System. Airway Inflammation is Linked to TRP channels. How Thermo-TRP's Regulate Longevity. TRP channels in the Brain: What Are They There For?

Descriere

Neurobiology of TRP channels will review the current knowledge on how these important proteins participate in physiological and pathophysiological processes. The book is includes chapters by experts on the role of TRP channels in the peripheral and central nervous system.