In this issue of Veterinary Clinics of North America: Food Animal Practice, guest editors Drs. Nial J. O'Boyle, John Dustin Loy, and Jessica L. Klabnik bring their considerable expertise to the topic of Genomics. Top experts provide a primer on fundamentals, applications, and implementation of genetics and genomics into ruminant practice, including articles on key genetics/genomics strategies and economic impact; sampling and laboratory logistics; beef and dairy genetic evaluations; and the role of veterinary practitioners in the genomic era in beef and dairy.