Structure and Intrinsic Disorder in Enzymology: Foundations and Frontiers in Enzymology
Editat de Munishwar Nath Gupta, Vladimir N. Uverskyen Limba Engleză Paperback – 21 noi 2022
Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.
- Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins
- Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study
- Features chapter contributions from international leaders in the field
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Specificații
ISBN-13: 9780323995337
ISBN-10: 0323995330
Pagini: 528
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Foundations and Frontiers in Enzymology
ISBN-10: 0323995330
Pagini: 528
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Foundations and Frontiers in Enzymology
Public țintă
Basic and translational researchers in biochemistry, biotechnology, molecular biology, cellular biology, genetics, pathology, chemistry, and pharmaceutical science; life science researchers; developmental biologistsclinicians and graduate students in the biosciences
Cuprins
1. Enzymology: Early insights 2. Deep mutational scanning to probe specificity determinants. 3. Protein flexibility and cryo-enzymology: The trade-off between stability andcatalytic rates 4. Thermodynamic Perspective of Protein Disorder and Phase Separation: Model Systems 5. Structure and disorder: Protein functions depend on this new binary transforming lock-and-key into structure-function continuum 6. Methods for measuring structural disorder in proteins 7. Prediction of protein structure and intrinsic disorder in the era of deep learning 8. Roles of Intrinsically Disordered Regions in Phosphoinositide 3-Kinase Biocatalysis 9. Many faces of protein promiscuity: Not just broad specificity of proteins 10. Role Of Plasticity And Disorder In Protein Moonlighting: Blurring Of Lines Between Biocatalysts And Other Biologically Active Proteins 11. Molten globular enzymes 12. Intrinsic disorder and allosteric regulation 13. Macromolecular Crowding: How it Affects Protein Structure, Disorder, and Catalysis 14. Intrinsic disorder and post-translational modifications: An evolutionary perspective 15. The roles of prion-like domains in amyloid formation, phase separation, and solubility 16. IDPRs of membrane proteins influence membrane curvature 17. How binding to surfaces affects disorder