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Green Chemistry in Drug Discovery: From Academia to Industry de Paul F. Richardson

Green Chemistry in Drug Discovery: From Academia to Industry: Methods in Pharmacology and Toxicology

Editat de Paul F. Richardson
en Limba Engleză Paperback – 14 dec 2021
This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. 

Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist forthese techniques to be effectively implemented in the drug discovery process in a routine manner.
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Specificații

ISBN-13: 9781071620335
ISBN-10: 1071620339
Pagini: 617
Ilustrații: XVI, 617 p. 609 illus., 19 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 1.08 kg
Ediția:1st ed. 2022
Editura: Springer
Colecția Humana
Seria Methods in Pharmacology and Toxicology

Locul publicării:New York, NY, United States

Cuprins

Green Synthesis of Common Heterocycles.- Greener Methods for Amide Bond Synthesis.- Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications.- Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update.- Friedel-Crafts Reactions.- Ionic Liquids: Design and Applications.- Designing Efficient Cascade Reactions in Drug Discovery.- Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles.- Direct C–H Functionalization Approaches to Pharmaceutically Relevant Molecules.- C–H Activation with Photoredox Catalysis.- In Situ Protecting Groups for Chemoselective Transformations.- Expanding the Biocatalysis Toolbox.- New Directions in Coupling Chemistry.- Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry.- Reaction Optimization: A High-Throughput Experimentation Approach.- Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry.

Notă biografică

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Textul de pe ultima copertă

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. 

Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist forthese techniques to be effectively implemented in the drug discovery process in a routine manner.

Caracteristici

Contains key implementation advice from the experts Includes practical techniques Provides step-by-step detail for reproducible results