Myosins (Advances in Experimental Medicine and Biology) de Lynne M. Coluccio

Myosins: A Superfamily of Molecular Motors: Advances in Experimental Medicine and Biology, cartea 1239

Lynne M. Coluccio

Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact.

Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.

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Hardback (2)	1215^.81 lei 6-8 săpt.
SPRINGER NETHERLANDS – 30 noi 2007	1215^.81 lei 6-8 săpt.
Springer International Publishing – 26 mai 2020	1338^.46 lei 38-44 zile

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1215^.81 lei 6-8 săpt.

SPRINGER NETHERLANDS – 30 noi 2007

1215^.81 lei 6-8 săpt.

Springer International Publishing – 26 mai 2020

1338^.46 lei 38-44 zile

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Specificații

ISBN-13: 9783030380618
ISBN-10: 3030380610
Pagini: 455
Ilustrații: XI, 455 p. 116 illus., 97 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 1 kg
Ediția:2nd ed. 2020
Editura: Springer International Publishing
Colecția Springer
Seria Advances in Experimental Medicine and Biology

Locul publicării:Cham, Switzerland

Cuprins

Introduction.- Myosin Structure.- Cargo Binding by Unconventional Myosins.- Cryo-EM of Actin-Myosin Structures.- Small Molecule Effectors of Myosin Function.- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction.- High-Speed Atomic Force Microscopy to Study Myosin Motility.- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches.- How Actin Tracks Affect Myosin Motors.- Myosins in the Nucleus.- Myosins in Cytokinesis.- Myosins and Disease.- Myosins and Hearing.- The Actomyosin Systems in Apicomplexa.- Approaches to Identify and Characterise MYO6-Cargo Interactions.- Class IX Myosins: Motorized RhoGAP Signaling Molecules.- Myosin X.- Myosin XVI.- Myosin XVIII.- Myosin XIX

Notă biografică

Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.

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