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Protein Dynamics: Experimental and Computational Approaches: Foundations and Frontiers in Enzymology

Editat de Durba Sengupta, Ana-Nicoleta Bondar
en Limba Engleză Paperback – sep 2025
Protein Dynamics: Experimental and Computational Approaches investigates protein biology from a biophysical standpoint. The book covers a wide range of topics including functional protein dynamics, intrinsically disordered proteins, protein folding, misfolding and aggregation, and membrane protein-protein communication. Protein allosteric conformational changes caused by drug binding and disease-associated mutations is also featured, alongside protein dynamics in the context of computer-based drug design. Biophysical techniques for investigating protein structure-dynamics-function relationships across these topics are explored, considering the latest experimental and computational approaches in the field. This book is an ideal reference for researchers in working in biophysics, biochemistry, and related areas.

  • Covers a broad range of biophysical techniques to study protein dynamics
  • Investigates an array of different proteins, including receptors, transporters and enzymes
  • Considers future directions in the field
  • Features explanation of key concepts and end-of-chapter questions to aid understanding
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Specificații

ISBN-13: 9780443300424
ISBN-10: 0443300429
Pagini: 442
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Foundations and Frontiers in Enzymology


Cuprins

1. Introduction
2. Functional protein dynamics
3. Protein-protein communication in membrane protein organization and cell signaling
4. Intrinsically disordered proteins
5. Role of entropy in protein folding
6. Functional water molecules and role of ions in protein function
7. Computing transition states in enzyme reactions
8. G Protein Receptor Signaling
9. Protonation-coupled protein dynamics studied with graph algorithms
10. Membrane transporters
11. Lipids and lipid-protein dynamics in membrane protein function
12. Protein misfolding and aggregation
13. Proteins of extremophiles
14. Protein allosteric conformational changes caused by drug binding and disease-associated mutations
15. Computer-based drug design
16. Amyloid precursor protein in Alzheimer’s disease