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Purification of Biotechnological Products: A Focus on Industrial Applications: Drugs and the Pharmaceutical Sciences

Editat de Adalberto Pessoa Jr, Beatriz Vahan Kilikian, Paul Long
en Limba Engleză Hardback – 23 mai 2024
This outstanding text focuses on providing professionals and students working in the pharmaceutical and biotechnology field with the background necessary for developing of a product or process and with the necessary rigor required by federal regulatory agencies in the pharmaceutical industry. The material will enable teachers, lecturers and professors in biotechnology to prepare courses on basic concepts and applications for the purification of biotechnological products of industrial interest. These can be applied in practice, for example, with projects on purification development on an industrial scale or useful unit operations for the development of bioproducts of commercial interest.
Features:
  • Purification and development of new bioproducts and improvement of those being produced
  • Provides a background and concepts on the purification of biomolecules and with an industrial perspective
  • It allows professionals to understand the entire process of developing a biopharmaceutical or bio-food, from bench to industry in biotechnology; one of the fastest-growing sectors of the economy
  • It promotes the dissemination of information in a didactic way which is of paramount importance for interdisciplinary fields
  • It enables the reader to follow step-by-step stages of the development of a new biopharmaceutical, and allows the optimization of existing processes
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Specificații

ISBN-13: 9781032704241
ISBN-10: 1032704241
Pagini: 538
Ilustrații: 594
Dimensiuni: 178 x 254 mm
Greutate: 1.16 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Drugs and the Pharmaceutical Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic, Postgraduate, Professional Practice & Development, Professional Training, and Undergraduate Advanced

Cuprins

Chapter 1 Introduction       
Chapter 2 Purification processes: analytical methods and enzyme stability           
Chapter 3 Cell Disruption   
Chapter 4 Filtration and Centrifugation   
Chapter 5 Membrane Separation Processes         
Chapter 6 Protein Precipitation     
Chapter 7 Liquid-liquid extraction in aqueous two-phase systems           
Chapter 8 Introduction to chromatography         
Chapter 9 Size exclusion chromatography           
Chapter 10 Iion Exchange chromatography         
Chapter 11 Hydrophobic interaction chromatography   
Chapter 12 Affinity Chromatography       
Chapter 13 Adsorption chromatography in monolithic columns            
Chapter 14 Chromatography: expanded bed adsorption (EBA)
Chapter 15 Continuous Chromatography using a Simulated Moving Bed System 
Chapter 16 Chromatography scale-up      
Chapter 17 Crystallization 
Chapter 18 Distillation          
Chapter 19 Plasmid Purification   
Chapter 20 Purification of monoclonal antibodies           
Chapter 21 Peptides of biotechnological interest: general concepts, production, purification and chemical characterization           
Chapter 22 Integration of steps in the production of biotechnological products   

Notă biografică

Dr. Adalberto Pessoa Jr., Full professor at the School of Pharmaceutical Sciences, Biochemical-Pharmaceutical Technology Department, of the University of São Paulo and Visiting Professor at King’s College London, Institute of Pharmaceutical Science. He has experience in fermentation technology and in the purification processes of biotechnological products of interest to the pharmaceutical and food industries.
Dr. Beatriz Vahan Kilikian, nowadays retired, she was Associate Professor at the Polytechnic School of the University of São Paulo, from 1983 to 2012. She has experience in microrganisms cultivation and in the purification processes of biotechnological products of interest to the pharmaceutical, chemical and food industries.
Dr. Paul Frederick Long Full Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. Prof Long is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

Descriere

This unique text provides a background and concepts related to the purification of biomolecules and with an industrial perspective.