RNA Interference and Cancer Therapy de Lekha Dinesh Kumar

RNA Interference and Cancer Therapy: Methods and Protocols: Methods in Molecular Biology, cartea 1974

Lekha Dinesh Kumar

This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research. Exploring the immense ‘bench to bedside’ potential of RNAi as a therapeutic molecule, the book focuses many of its chapters on nanoparticle-based targeted deliveries, including aptamers, as well as techniques for using RNAi technology to combat various cancers in preclinical studies. Each of the 26 chapters is authored by the pioneers in the respective areas and thus provides a practical and empirical account of the techniques that could be used as benchmark tools in the area of cancer research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and essential, RNA Interference and Cancer Therapy: Methods and Protocols provides the necessary guidance for both novice and professional researchers who intend to discover and innovate newer means of using RNAi technology to combat cancer, one of the greatest scourges of human health.

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Cuprins

siRNA Library Screening to Identify Complementary Therapeutic Pairs in Triple Negative Breast Cancer Cells.- In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy.- siRNA-Based Drug Targeting Human Bcl-xL against Cancers.- Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly-Active siRNAs.- VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrier.- Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” that Can Conditionally Release their Cargo.- Combinatorial siRNA Polyplexes for Receptor Targeting.- Synthesis of Doxorubicin and miRNA Stimuli-Sensitive Conjugates for Combination Therapy.- Minicell-Based Targeted Delivery of shRNA to Cancer Cells: An Experimental Protocol.- Targeted Delivery of miRNA Antagonists to Myeloid Cells In Vitro and In Vivo.- Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles.- Targeting Cancer with Peptide RNAi Nanoplexes.- Preparation of a Carrier to Achieve In Vivo Delivery of siRNA: The Example of Chitosan-Coated Poly(isobutylcyanoacrylate) Nanoparticles.- Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery.- Synthesis of Gold Nanoparticles for Gene Silencing.- Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment.- ⁶⁴Cu-Labeled Aptamers for Tumor-Targeted Radionuclide Delivery.- Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer.- Bio-Drug Suppresses Breast and Colorectal Cancer in Murine Models.- Combinatorial Nanoparticle Delivery of siRNA and Antineoplastics for Lung Cancer Treatment.- Bioconjugated Gold Nanoparticles Enhance siRNA Delivery in Prostate Cancer Cells.- Vaginal Suppositories with siRNA and Paclitaxel-Incorporated Solid Lipid Nanoparticles for Cervical Cancer: Preparation and In Vitro Evaluation.- The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models.- Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer.- Synthesis, Physico-Chemical, and Biological Evaluation of Spherical Nucleic Acids for RNAi-Based Therapy in Glioblastoma.- Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy.

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RNA Interference and Cancer Therapy: Methods and Protocols: Methods in Molecular Biology, cartea 1974

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