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Structural and Functional Characterization of the Immunoproteasome: Springer Theses

Autor Eva Maria Huber
en Limba Engleză Hardback – oct 2013
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
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Specificații

ISBN-13: 9783319015552
ISBN-10: 3319015559
Pagini: 104
Ilustrații: XIX, 82 p. 33 illus., 29 illus. in color.
Dimensiuni: 155 x 235 x 11 mm
Greutate: 0.3 kg
Ediția:2013
Editura: Springer International Publishing
Colecția Springer
Seria Springer Theses

Locul publicării:Cham, Switzerland

Public țintă

Research

Cuprins

Introduction.- Objective.- Materials and Methods.- Results.- Discussion.- Appendix.

Notă biografică

Eva Huber studied biochemistry at the Technische Universität München (TUM) from 2004 till 2009. For her master studies, which were funded by the Studienstiftung des deutschen Volkes, she received the Jürgen-Manchot Studienpreis from the faculty of chemistry of the TUM. During her postgraduate studies (2009-2013) in the group of Prof. Groll at the TUM she succeeded in the elucidation of the mouse immuno- and constitutive proteasome X-ray structures in their unliganded state and in complex with the immunoproteasome-selective compound ONX 0914. For these results she has been awarded the “Management Engineers Presidential Award” in 2012.

Textul de pe ultima copertă

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Caracteristici

Nominated as an outstanding Ph.D. thesis by the Technische Universität München, Germany Detailed analysis of the X-ray structures of the murine immune- and constitutive proteasome Yeast mutagenesis study to explore the differences between the constitutive proteasome, the immunoproteasome and the thymoproteasome Inhibition studies on the immunoproteasome-selective compound ONX 0914 Includes supplementary material: sn.pub/extras