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Structural Genomics and Drug Discovery: Methods and Protocols: Methods in Molecular Biology, cartea 1140

Editat de Wayne F. Anderson
en Limba Engleză Hardback – 4 mar 2014
Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.
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Specificații

ISBN-13: 9781493903535
ISBN-10: 1493903535
Pagini: 330
Ilustrații: XV, 344 p. 78 illus., 64 illus. in color.
Dimensiuni: 178 x 254 x 20 mm
Greutate: 1.09 kg
Ediția:2014
Editura: Springer
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

Data Management in the Modern Structural Biology and Biomedical Research Environment.- Structural Genomics of Human Proteins.- Target Selection for Structural Genomics of Infectious Diseases.- Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery.- High Throughput Cloning for Biophysical Applications.- Expression and Solubility Testing in a High Throughput Environment.- Protein Production for Structural Genomics Using E. coli Expression.- Eukaryotic Expression Systems for Structural Studies.- Automated Cell-free Protein Production Methods for Structural Studies.- Parallel Protein Purification.- Oxidative Refolding from Inclusion Bodies.- High throughput Crystallization Screening.- Screening Proteins for NMR Suitability.- Salvage or Recovery of Failed Targets by in situ Proteolysis.- Salvage of Failed Protein Targets by Reductive Alkylation.- Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy.- Data Collection for Crystallographic Structure Determination.- Structure, Determination, Refinement, and Validation.- Virtual High-Throughput Ligand Screening.- Ligand Screening using Fluorescence Thermal Shift Analysis (FTS).- Ligand Screening using Enzymatic Assays.- Ligand Screening using NMR.- Screening Ligands by X-ray Crystallography.- Case Study – Structural Genomics and Human Protein Kinases.

Textul de pe ultima copertă

Structural Genomics and Drug Discovery: Methods and Protocols focuses  on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery.​Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
 
Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.

Caracteristici

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts Includes supplementary material: sn.pub/extras