Target Discovery and Validation Reviews and Protocols: Emerging Strategies for Targets and Biomarker Discovery, Volume 1: Methods in Molecular Biology, cartea 360
Editat de Mouldy Siouden Limba Engleză Hardback – 15 oct 2006
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Specificații
ISBN-13: 9781588296566
ISBN-10: 1588296563
Pagini: 368
Ilustrații: XII, 354 p. 89 illus., 3 illus. in color.
Dimensiuni: 152 x 229 x 28 mm
Greutate: 0.69 kg
Ediția:2007
Editura: Humana Press Inc.
Colecția Humana
Seria Methods in Molecular Biology
Locul publicării:Totowa, NJ, United States
ISBN-10: 1588296563
Pagini: 368
Ilustrații: XII, 354 p. 89 illus., 3 illus. in color.
Dimensiuni: 152 x 229 x 28 mm
Greutate: 0.69 kg
Ediția:2007
Editura: Humana Press Inc.
Colecția Humana
Seria Methods in Molecular Biology
Locul publicării:Totowa, NJ, United States
Public țintă
Professional/practitionerCuprins
Main Approaches to Target Discovery and Validation.- Bioinformatics Approaches to Cancer Gene Discovery.- Analysis of Gene Networks for Drug Target Discovery and Validation.- Target Discovery and Validation in Pancreatic Cancer.- Molecular Classification of Breast Tumors.- Discovery of Differentially Expressed Genes.- Genome-Wide Screening by Using Small-Interfering RNA-Expression Libraries.- Hammerhead Ribozyme-Based Target Discovery.- Production of siRNA and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells.- Transgenic Animal Models in Biomedical Research.- Keratin Transgenic and Knockout Mice.- The HUVEC/Matrigel Assay.- A Murine Model for Studying Hematopoiesis and Immunity in Heart Failure.- An Overview of the Immune System and Technical Advances in Tumor Antigen Discovery and Validation.- Potential Target Antigens for Immunotherapy Identified by Serological Expression Cloning (SEREX).- Identification of Tumor Antigens by Using Proteomics.- Protein Arrays.
Recenzii
From the reviews:
"Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. … Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. … provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application." (Anticancer Research, Vol. 27, May, 2007)
"Review current methods for drug target discovery and validation. … Volume 1 is focused on drug target and biomarker discovery. … the chapters are generally well written and clear, and provide extensive references to the current literature. … Overall … provide useful overviews that would provide entry into this field. Novice and more experienced researchers … would find useful information … ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)
"Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. … Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. … provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application." (Anticancer Research, Vol. 27, May, 2007)
"Review current methods for drug target discovery and validation. … Volume 1 is focused on drug target and biomarker discovery. … the chapters are generally well written and clear, and provide extensive references to the current literature. … Overall … provide useful overviews that would provide entry into this field. Novice and more experienced researchers … would find useful information … ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)
Caracteristici
Includes supplementary material: sn.pub/extras