Cantitate/Preț
Produs
Total produse
Vezi coșul
Drug Metabolism and Transport: Molecular Methods and Mechanisms de Lawrence H. Lash

Drug Metabolism and Transport: Molecular Methods and Mechanisms: Methods in Pharmacology and Toxicology

Editat de Lawrence H. Lash
en Limba Engleză Hardback – 24 sep 2004
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 110100 lei  43-57 zile
  Humana Press Inc. – 9 noi 2010 110100 lei  43-57 zile
Hardback (1) 110923 lei  43-57 zile
  Humana Press Inc. – 24 sep 2004 110923 lei  43-57 zile

Din seria Methods in Pharmacology and Toxicology

  • 5% G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era
    Preț: 111491 lei
  • 5% The Handbook of Metabolomics
    Preț: 112040 lei
  • 5% Nanomaterials in Pharmacology
    Preț: 131003 lei
  • 5% Computational Systems Toxicology
    Preț: 70910 lei
  • 5% Apoptosis Methods in Toxicology
    Preț: 104982 lei
  • 5% Cardiac Drug Development Guide
    Preț: 105825 lei
  • 5% Toxicity and Biodegradation Testing
    Preț: 111491 lei
  • 5% Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications
    Preț: 110669 lei
  • 5% Multi-Target Drug Design Using Chem-Bioinformatic Approaches
    Preț: 163116 lei
  • 5% Optimization in Drug Discovery: In Vitro Methods
    Preț: 104229 lei
  • 5% Stem Cell-Derived Models in Toxicology
    Preț: 73236 lei
  • 5% Herbal Medicines: New Horizons
    Preț: 104269 lei
  • 5% In Vitro Toxicology Systems
    Preț: 163241 lei
  • 5% Genotoxicity and DNA Repair: A Practical Approach
    Preț: 112055 lei
  • 5% TRP Channels in Drug Discovery: Volume II
    Preț: 136285 lei
  • 5% Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture
    Preț: 70474 lei
  • 5% Biomarker Methods in Drug Discovery and Development
    Preț: 101004 lei
  • 5% Methods for Stability Testing of Pharmaceuticals
    Preț: 85982 lei
  • 5% Antibiotic Pharmacodynamics
    Preț: 113318 lei
  • 5% Immunotherapy and Biomarkers in Neurodegenerative Disorders
    Preț: 72852 lei
  • 5% Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
    Preț: 70841 lei
  • 5% G Protein-Coupled Receptor Kinases
    Preț: 73164 lei
  • 5% Cancer Prevention: Dietary Factors and Pharmacology
    Preț: 110669 lei
  • 5% Antiepileptic Drug Discovery: Novel Approaches
    Preț: 73546 lei
  • 5% Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
    Preț: 72248 lei
  • 5% Ocular Pharmacology and Toxicology
    Preț: 130692 lei
  • 5% Histamine Receptors as Drug Targets
    Preț: 112333 lei
  • 5% Label-Free Biosensor Methods in Drug Discovery
    Preț: 73583 lei
  • 5% Developmental and Reproductive Toxicology
    Preț: 110908 lei
  • 5% In Vitro Neurotoxicology: Principles and Challenges
    Preț: 72744 lei
  • 5% Integrin Targeting Systems for Tumor Diagnosis and Therapy
    Preț: 72450 lei
  • 5% Ion Channel Localization
    Preț: 111694 lei
  • 5% Drug-Induced Liver Toxicity
    Preț: 94448 lei
  • 5% Computer-Aided Drug Discovery
    Preț: 104542 lei

Preț: 110923 lei

Preț vechi: 116761 lei
-5% Nou

Puncte Express: 1664
Preț estimativ în valută:
21227€ • 22027$ • 17743£

Carte tipărită la comandă

Livrare economică 17-31 martie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9781588293244
ISBN-10: 1588293246
Pagini: 388
Ilustrații: X, 388 p. 110 illus.
Dimensiuni: 155 x 235 x 30 mm
Greutate: 0.79 kg
Ediția:2005
Editura: Humana Press Inc.
Colecția Humana
Seria Methods in Pharmacology and Toxicology

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Renal Cytochrome P450s and Flavin-Containing Monooxygenases.- Experimental Approaches for the Study of Cytochrome P450 Gene Regulation.- Insulin and Growth Factor Signaling.- Catalytic Function and Expression of Glutathione Transferase Zeta.- Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases.- Transcriptional Regulation of UDP-Glucuronosyltransferases.- Phenotypic and Genotypic Characterization of N-Acetylation.- Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen.- Modulation of Drug Metabolism and Antiviral Therapies.- Modulation of Thiols and Other Low-Molecular-Weight Cofactors.- Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics.- Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier.- Glutathione Transport in the Kidneys.- Human Cytosolic Sulfotransferases.

Recenzii

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

Textul de pe ultima copertă

Remarkable advances in molecular and cell biology and the development of novel in vitro model systems have greatly expanded our knowledge of the processes involved in metabolism and transport and led to numerous new therapeutic approaches. In Drug Metabolism and Transport: Molecular Methods and Mechanisms, well-established investigators describe their best experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems. Many chapters contain step-by-step methods for investigating metabolism and transport.
Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.