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Freeze Drying of Pharmaceutical Products de Davide Fissore

Freeze Drying of Pharmaceutical Products: Advances in Drying Science and Technology

Editat de Davide Fissore, Roberto Pisano, Antonello Barresi
en Limba Engleză Paperback – 30 iun 2021
Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development.


This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia. It was contributed to by lyophilization experts to create a detailed analysis of the subject matter, organically presenting recent advancements in freeze-drying research and technology. It discusses formulation design, process optimization and control, new PAT-monitoring tools, multivariate image analysis, process scale-down and development using small-scale freeze-dryers, use of CFD for equipment design, and development of continuous processes.


This book is for industry professionals, including chemical engineers and pharmaceutical scientists.
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Specificații

ISBN-13: 9781032085906
ISBN-10: 1032085908
Pagini: 212
Ilustrații: 4 Illustrations, color; 66 Illustrations, black and white
Dimensiuni: 156 x 234 mm
Greutate: 0.39 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Advances in Drying Science and Technology

Public țintă

Professional Practice & Development

Cuprins

1. Formulation Design and Optimization Using Molecular Dynamics. 2. Established and Novel Excipients for Freeze-Drying of Proteins. 3. Multivariate Image Analysis: A New PAT for Freeze-Drying Monitoring. 4. Impedance Methods for Process Monitoring. 5. Innovations in Freeze-Drying Control and In-Line Optimization. 6. Process Design, Optimization and Scale-Up Using Micro Freeze-Dryers. 7. Continuous Freeze-Drying. 8. Pat for Batch and Continuous Freeze-Drying Processes. 9. Use of CFD for the Design and Optimization of Freeze-Dryers.

Notă biografică

Davide Fissore is Professor of Chemical Engineering at Politecnico di Torino (Italy). His research activity is mainly focused on process modelling and optimisation, and on the design and validation of model-based tools for process monitoring and control. One of the topics of his research activity is the freeze-drying of pharmaceutical products and foodstuffs. He developed various devices to monitor and optimise in-line (using a control system) or offline (using the design space of the product) the freeze-drying process for a given product. He acted as a consultant of several pharmaceutical companies, focusing on process development and scale-up. Davide Fissore is author or co-author of 89 papers appeared in international peer reviewed journals, 15 book chapters and currently holds 9 patents, issued or pending.




Roberto Pisano is a Professor of Chemical Engineering at Politecnico di Torino (Italy), where he received his Ph.D. in 2009. Professor Pisano’s research focuses on the application of both computational and experimental methods to engineering chemical products and processes, with particular emphasis to pharmaceutical processing and formulation of both small molecules and biologics. He has been visitor researcher at Centre de Ressources Technologiques – Institut Technique Agro-Industriel (Strasbourg, France) in 2008, and at the Department of Chemical Engineering of Massachusetts Institute of Technology (Cambridge, USA) in 2016. He has worked with many pharmaceutical companies in research or consulting. He has published more than 75 papers, 7 book chapters, and currently has 4 patents issued or pending.




Antonello Barresi is currently full professor of Transport Phenomena at Politecnico di Torino, in charge of the course of Process Development and Design. Currently Italian national delegate in the Working Party on Drying of the European Federation of Chemical Engineers. His main research interests in drying include: drying and freeze drying of pharmaceuticals and enzymes, modelling and optimization of freeze-drying processes, control of industrial freeze-dryers. Most recent research is focused on process transfer, scale-up and cycle development, and new approaches for process development and quality control in freeze-drying of pharmaceutical and food products. Author of more than 250 papers (of which about 160 published on international journals or books) and more than 100 Conference presentations.

Descriere

This book provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring, and considering new technologies for process development.